Ufmylation在文献中是什么意思

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August undefined, 2024

Web23 Jun 2024 · Noticeably, an aberrant UFM1 modification system has been closely related to various types of tumorigeneses, implying that the restoration of UFMylation homeostasis may serve as a promising therapeutic strategy. In this review, we summarize the structure, process and biological functions of the UFM1 modification system. Web1 Oct 2024 · The Ubiquitin-fold modifier 1 (Ufm1) is a ubiquitin-like protein that can also be conjugated to protein substrates and subsequently alter their fates.Both UFMylation and de-UFMylation are mediated by Ufm1-specific proteases (UFSPs).In humans, it is widely believed that UFSP2 is the only active Ufm1 protease involved in Ufm1 maturation and de …

NCB UFMylation修饰在维持p53肿瘤抑制功能上的重要性

Web1 Mar 2024 · It is reported that ufmylation participates in non-alcoholic steatohepatitis, hematopoietic anemia, hip dysplasia, neural system diseases, proliferation and … Web1 Jun 2016 · The ufmylation of ASC1 is important for the transactivation of ERα and thus breast cancer development [17].In addition, UfBP1 knockdown compromises cell proliferation and invasion in human osteosarcoma U2OS cells [46].However, both UFL1 and UfBP1 have been reported to suppress the NF-κB signaling pathway [46].Thus, the … ions te

Modification of ASC1 by UFM1 is crucial for ERα ... - PubMed

Web21 Dec 2024 · Here we demonstrated that (1) an ER membrane-localizing reductase, CYB5R3, is a bona fide UFM1 substrate; (2) ufmylated CYB5R3 interacts with the E3 ligase component UFBP1 to facilitate further ... Web20 Jan 2024 · As UFMylation is a dynamic reversible process in cells, we discuss how proteases regulate this PTM. We then discuss the role of UFMylation in ER homeostasis … ion stay

杭州师范大学Nature子刊首次报道Ufmylation修饰的内质网稳态维 …

Web20 Aug 2024 · 医学院丛羽生教授团队在Nature Cell Biology上发表最新研究成果. 8月17日，医学院、浙江省衰老与癌变生物学重点实验室丛羽生教授团队在Nature Cell Biology（IF2024: 20.042）上在线发表了肿瘤抑制因子p53类泛素化修饰调控的最新研究成果“ UFMylation maintains tumor suppressor p53 ... Web18 Mar 2024 · Here we report that UFM1 specific ligase 1 (UFL1), an ufmylation E3 ligase, is important for ATM activation. UFL1 is recruited to double strand breaks by the MRE11/RAD50/NBS1 complex, and ... on the go joy bundle upWeb14 Mar 2024 · UFMyla …. Immunotherapy of PD-L1/PD-1 blockage elicited impressive clinical benefits for cancer treatment. However, the relative low response and therapy … on-the-go joy savvy boot

"Web39 ubiquitin-like modifier conjugation system called ufmylation, UFL1, as one of the proteins 40 recruited to membranes at ER-mitochondrial contact sites in response to RIG-I activation. 41 Here, we show that UFL1, as well as the process of ufmylation, promote IFN induction in 42 response to RIG-I activation. " - Ufmylation在文献中是什么意思

Ufmylation在文献中是什么意思

Nontraditional translation is the key to UFMylation and beyond

Web1 Jun 2016 · Ubiquitin (Ub) is conjugated to its target proteins by an elaborate enzymatic reaction chain, which consists of an activating enzyme E1, a conjugating enzyme E2, and … Web问题：DDRGK1是如何介导UFMylation发生的？实验验证：之前研究表明UFM1对DDRGK1的UFMylation依赖于DDRGK1上的赖氨酸（K）位点（Fig5A）。免疫沉淀实验发现DDRGK1 …

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WebThough the function of ufmylation in ER stress and autophagy has been described in mammals, their detailed roles in plant development and stress responses remain elusive. … Web23 Jun 2024 · Metformin can induce ferroptosis. Ferroptosis is an iron-dependent form of cell death [].Metformin can promote accumulation of iron ions, and DFO, as a ferroptosis inhibitor, can effectively inhibit the anti-cancer effect of metformin (Fig. 1c and d). Therefore, we hypothesized that the anti-cancer effect could be at least partly explained by …

http://cjbmb.bjmu.edu.cn/CN/Y2024/V35/I3/229 Web19 Sep 2024 · Besides ubiquitin (Ub), humans have a set of ubiquitin-like proteins (UBLs) that can also covalently modify target proteins. To date, less is known about UBLs than Ub and even less is known about the UBL called ubiquitin-fold modifier 1 (UFM1). Currently, our understanding of protein modification by UFM1 (UFMylation) is like a jigsaw puzzle with …

Web9 Mar 2024 · UFMylation of PD-L1 destabilizes PD-L1 by synergizing its ubiquitination. Inhibition of PD-L1 UFMylation via silencing of UFL1 or Ubiquitin-fold modifier 1 (UFM1), … Web8 Oct 2024 · UFM1 is a small ubiquitin-like modifier essential for cell differentiation and animal development. 23,24,25,26 Mutations in genes encoding human UFMylation …

Web1 Oct 2024 · Both UFMylation and de-UFMylation are mediated by Ufm1-specific proteases (UFSPs). In humans, it is widely believed that UFSP2 is the only active Ufm1 protease …

Ubiquitin-fold modifier 1, also known as UFM1, is a protein which in humans is encoded by the UFM1 gene. UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 and E2-like conjugating enzyme UFC1. This process is often referred to as UFMylation. ion sterian transgazWeb19 Aug 2024 · UFMylation修饰（UFM1修饰）是最新被鉴定的一种类泛素化修饰【2,3】，与泛素化修饰类似，UFM1以前体形式被合成，经过UfSP1或UfSP2剪切，形成活化的UFM1 … on the go jack linkletterWeb2024年3月10日，加州大学伯克利分校Jacob E. Corn研究组在Cell上发表文章A Genome-wide ER-Phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation，针对内质网自噬以ER-phagy报告基因为筛选背景展开了全基因基础的筛选，发现并鉴定出200多个与人类内质网自噬相关的因子，揭开了内质网自噬依赖于 ... on the go jo coffeeWebThe ubiquitin-fold modifier 1 (UFM1) is a post-translational modifier discovered a decade ago but its biological significance remained mostly unknown. The field recently witnessed … on the go jewelry caseWebC53 senses ER stress by forming a tripartite receptor complex that involves UFL1, the E3 ligase that mediates ufmylation, and its ER-resident adaptor protein DDRGK1. C53 activity is regulated by another ubiquitin-like protein, UFM1, which is transferred from C53 to the ribosomes upon ribosome collision/stalling at the ER, thereby activating the C53 pathway … ion sterianWeb20 Jan 2024 · Based on the impact of mutations in UFMylation components in several diseases and data from murine studies and cellular models, we suggest possible mechanisms by which UFMylation may maintain cellular homeostasis: (a) UFM1 is required either for quality control of secretory proteins or to support a collagen-specialized … ionstech unique fiber repair shaperWeb17 May 2024 · Aberrations in protein modification with ubiquitin-fold modifier (UFM1) are associated with a range of diseases, but the biological function and regulation of this post-translational modification, known as UFMylation, remain enigmatic. To provide activity-based probes for UFMylation, we have developed a new method for the installation of … on the go joy snow boot