WebJun 15, 2015 · Irf1 binding motif was enriched in the promoters of Batf2-regulated genes. Coimmunoprecipitation study demonstrated Batf2 association with Irf1. Furthermore, Irf1 knockdown showed downregulation of IFN-γ– or LPS/HKTB-activated host-protective genes Tnf, Ccl5, Il12b, and Nos2. WebJul 22, 2016 · Among up-regulated genes we found a significant percentage (142/224; 63%) had an IRF1 binding motif in the promoter region (from −950 bp to +50 bp) and are summarized in Fig. 5E and Supporting ...

IRF1 - an overview ScienceDirect Topics

Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta, IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes. IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protei… WebNov 1, 2011 · To validate the IRF1 binding motif, we performed another run of IRF1 ChIP-seq which included an independent pair of input DNA and IRF1 ChIP-seq samples. Although both samples had substantially lower numbers of aligned reads (20.4 and 20.7 millions … Introduction. The differentiation of CD4 + T cells into type 1 (Th1) or type 2 (Th2) T … Viral infections commonly induce expression of type I interferon (IFN) … Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 … Little is known about the molecular mechanisms and transcriptional … Total cellular protein was prepared from cell populations treated for 24 h with … portland oregon education

National Center for Biotechnology Information

WebApr 11, 2024 · IFNγ binds a specific cell-surface receptor complex, a heterodimer of IFNGR1 and IFNGR2, expressed in most cell types, which employ JAK1 and JAK2 to phosphorylate STAT1 (pSTAT1). pSTAT1 homodimers translocate to the nucleus and stimulate the expression of a set of genes, including transcription factors such as IFN regulatory factor … WebMay 12, 2024 · IRF1 counteracts IRF4-driven Il9 promoter activity, and IRF1 and IRF4 have opposing function on activating histone modifications, thus modulating RNA polymerase II recruitment. IRF1 occupancy... WebApr 3, 2024 · Mechanistically, upregulated ZEB1, by interacting with C-Terminal Binding Protein (CtBP), suppresses the transcription of IRF1 through binding to its promoter. In addition, IFN-γ can promote EMP in human nasal epithelial cells via p38/ERK mitogen activated protein (MAP) kinase signaling [ 146 ] and in prostate cancer via microRNA … portland oregon dump sites