Gephyronic acid

Author: mfrv

August undefined, 2024

WebGephyronic acid (hemiketal-beta) C26H46O7 CID 52952025 - structure, chemical … WebAug 29, 2024 · Here, we report the characterization of an atypical dehydratase (DH) domain from the PKS pathway for gephyronic acid, an inhibitor of eukaryotic protein synthesis. Using a library of synthetic substrate mimics, the reaction course, stereospecificity, and tolerance to non-native substrates of GphF DH1 are probed via LC-MS analysis.

Gephyronic Acid, a Missing Link between Polyketide Inhibitors …

WebDec 29, 2010 · Gephyronic Acid, a Missing Link between Polyketide Inhibitors of … WebInvestigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic … thermos1.12.2下载

Theoretical study on substrate recognition and catalytic …

WebMay 26, 2024 · Similar AT domains were reported in the biosynthetic gene cluster for gephyronic acid (module 2 and 4) , conglobatin (module 3) , and bengamide (module 3) . These AT domains also do not contain ... WebCoupled to the development of a total synthesis of gephyronic acid, a series of diastereomeric analogues and their precursors have been prepared by employing complementary aldol strategies for the ... WebAug 18, 2006 · Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part II): Total Synthesis of Gephyronic Acid. Angewandte Chemie International Edition 2011, 50 (4) , 942-945. DOI: 10.1002/anie.201005605. Holly A. Reichard, Martin McLaughlin, Ming Z. Chen, Glenn C. Micalizio. ... thermos 1155/3

Composes a effet antimycotique et cytostatique, leur procede de ...

Thiamyxins: Structure and Biosynthesis of Myxobacterial …

WebJul 31, 2024 · Gephyronic acid seems to have a different mode of action than the … WebFeb 8, 2010 · Richard Taylor from the Department of Chemistry and Biochemistry – to identify the key steps in the biosynthesis of gephyronic acid, a natural product isolated from a bacteria that has been shown to inhibit growth of yeast and mold, as well as a range of mammalian cell types. Identification of the gene cluster responsible for biosynthesis ... thermos 1.12.2WebA new antibiotic compound, gephyronic acid was isolated from the culture broth of the … thermos 12 can soft cooler green/grey

"Gephyronic acid is a polyketide that exists as an equilibrating mixture of structural isomers. In nature, gephyronic acid is produced by slow growing myxobacterium: Archangium gephyra strain Ar3895 and Cystobacter violaceus strain Cb vi76. It is the first antibiotic in myxobacteria that was reported … See more Preliminary studies demonstrated that gephyronic acid inhibited growth of yeast and molds as well as elicited a cytostatic effect through the inhibition of eukaryotic protein synthesis in mammalian cell cultures. Feeding … See more Sequencing of the PKS gene cluster in C. violaceus was conducted and confirmed to reveal five type I polyketide synthases and post-PKS tailoring enzymes with O-methyltransferase and cytochrome P450 monooxygenase. The overall structure correlates well with … See more " - Gephyronic acid

Gephyronic acid

WebAug 1, 2024 · Although the chemical structure of gephyronic acid, which resembled myriaporone 3/4 (25–26, Fig. 13), can switch between a keto and a hemiketal isomer, both forms have similar effects on the same cell type, suggesting that a quick equilibrium reaction takes place , . In mammalian cells, striking cytotoxic effects are observed, whereby …

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WebJan 7, 2024 · The structure and pathway annotation of gephyronic acid (Young et al., 2013) as well as initial biochemical characterization (Skiba et al., 2024) indicated that the GphF MT L converts Mal-ACP to Me 2 Mal-ACP via a MeMal-ACP intermediate (Figure 2 H). Thus, we tested the GphF GNAT selectivity for Me 2 Mal-ACP, MeMal-ACP and Mal … WebDec 23, 2010 · Solving the puzzle: The correct structure and configuration of the natural product gephyronic acid has been determined by NMR analysis and correlation with synthetic reference compounds, as well as with …

WebTheoretical study on substrate recognition and catalytic mechanisms of gephyronic acid dehydratase DH1† Lei Liu , ‡ a Qian Yu , ‡ a Haoqing Zhang , a Wentao Tao , a Rufan Wang , a Linquan Bai , a Yi-Lei Zhao a … WebJul 7, 2016 · In this work we establish the activity and substrate preference for six MTs from the gephyronic acid polyketide synthase and demonstrate their ability to methylate both N-acetylcysteamine- and acyl carrier protein-linked β-ketoacylthioester substrates but not malonyl thioester equivalents. These data strongly indicate that MT-catalyzed ...

WebGephyronic acid (hemiketal) C26H46O7 CID 52952026 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, … WebJul 31, 2024 · Gephyronic acid seems to have a different mode of action than the …

WebRolf Müller, R. Müller, 2004, Journal of Cancer Research and Clinical Oncology.

WebJan 11, 2024 · Gephyronic acid, a cytostatic polyketide produced by the myxobacterium … tpds1-2450ncwWebDec 3, 2013 · Gephyronic acid, a cytostatic polyketide produced by the myxobacterium … tpd publicrecords tucsonaz.govWebCoupled to the development of a total synthesis of gephyronic acid, a series of … tpd report lookupWebNov 27, 2024 · This study demonstrates that the GNAT-like domain in the PKS loading module for gephyronic acid biosynthesis is a highly selective Me 2 Mal-ACP decarboxylase and that it lacks acyl transfer activity. Based on the results for the myxobacterial GphF GNAT L and the cyanobacterial CurA GNAT L , decarboxylation is the primary role of … tpds 3x5WebAug 29, 2024 · Polyketide synthases (PKS) are a rich source of natural products of varied chemical composition and biological significance. Here, we report the characterization of an atypical dehydratase (DH) domain from the PKS pathway for gephyronic acid, an inhibitor of eukaryotic protein synthesis. Using a library of synthetic substrate mimics, the ... thermos 10 oz leak proof food jarWebGephyronic acid, a novel inhibitor of eukaryotic protein synthesis from Archangium gephyra (myxobacteria). Production, isolation, physico-chemical and biological properties, and mechanism of action. ... thermos 10 ounce funtainerWebFeb 7, 2007 · Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid. Angewandte Chemie International Edition 2011, 50 (4) , 938-941. DOI: 10.1002/anie.201005530. tpd representative form